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Zoloft (Sertraline hydrochloride) is used to treat depression, Doxycycline monohydrate vs hyclate anxiety disorders, Doxycycline monohydrate vs hyclate and obsessive-compulsive disorder. Zoloft belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amount of serotonin in the brain